Analysis performed on 2024-07-10 11:40:15
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 45268 | 593 | 44675 | 26467 |
| Archaea | 3397 | 114 | 3283 | 1424 |
| Vertebrata | 2692 | 1009 | 1683 | 465 |
| Mammals | 1071 | 128 | 943 | 134 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 723 | 8 | 607 |
| Domains | |
|---|---|
| Current Study | 1, 76 |
| Guo et al (2010) | 1, 80 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 648 | 75 | 723 | 8.640000 |
| Number of Variants | 555 | 60 | 615 | 9.250000 |
| Number of Pathogenic Variants | 7 | 1 | 8 | 7.000000 |
| Number of Benign/Unknown Variants | 548 | 59 | 607 | 9.288136 |
| Fisher exact test | 0.562290 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 643 | 80 | 723 | 8.037500 |
| Number of Variants | 553 | 62 | 615 | 8.919355 |
| Number of Pathogenic Variants | 7 | 1 | 8 | 7.000000 |
| Number of Benign/Unknown Variants | 546 | 61 | 607 | 8.950820 |
| Fisher exact test | 0.574829 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 648 | 75 | 0.90 (0.00) | 0.68 (0.02) | 9.481e-01 | 6.905e-01 | 41827.00 | 6.73e-25 |
| Guo et al (2010) | 643 | 80 | 0.90 (0.00) | 0.68 (0.02) | 9.488e-01 | 6.912e-01 | 44275.00 | 2.99e-26 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.